FDA Leadership Shake-Up: President Trump has nominated Dr. Heidi Overton, a White House policy aide, to lead the FDA, as the agency continues to operate without a permanent commissioner after recent leadership turbulence. Cancer Vaccine Breakthrough: Moderna and Merck reported a Phase 3 win for an individualized melanoma vaccine, saying it significantly delayed recurrence and spread versus Keytruda alone. Patient Safety Probe: Tennessee’s TBI is investigating a drug mix-up at a Nashville hospital that families say led to catastrophic complications in at least four patients. Health Tech & AI in Care: Oracle Health rolled out expanded AI agent features for clinical documentation, fee coding, and chart review, while regulators and clinicians continue debating how AI should be governed in medicine. Access & Outcomes: A study in JAMA Network Open links Medicaid expansion with better NSCLC coverage, earlier diagnosis, and improved survival. Digital Health Safety: The UK’s HSSIB flagged risks in NHS “Advice and Guidance” workflows, urging faster evaluation and better physician job planning. MedTech Partnership: Cleveland Clinic and Siemens Healthineers signed a new 10-year imaging and oncology partnership to upgrade care and training. Pharma Supply Chain & Manufacturing: Nigeria’s Emzor raised N26.7bn via bonds to expand drug production, including work on local antimalarial API manufacturing. E-Pharmacy Expansion: Pakistan’s Daraz launched a licensed e-pharmacy with OTC medicines delivered in 1–3 days. UTI Mechanism Insight: New research points to previously overlooked bladder nerves that may help reduce UTI burden by triggering pain and urgency responses.